Nov 7, 2020; Columbus, Ohio, USA; Ohio State Buckeyes quarterback Justin Fields (1) leads the team before the game against the Rutgers Scarlet Knights at Ohio Stadium. Mandatory Credit: Joseph Maiorana-USA TODAY Sports

NCAA Football Opening Lines Report

The opening lines for Week 12 in college football are loaded with large spreads, and there’s also three ranked matchups on the schedule.

Leading the ranked matchups is a Top 10 clash between No. 9 Indiana and No. 3 Ohio State. When Indiana vs Ohio State numbers were set for this game, the Buckeyes listed as a 19.5-point favorite. OSU has won 25 straight against Indiana, but don’t sleep on the Hoosiers here, as they are 7-1 ATS the last 8 times when dogs of 20 or more points.

(Indiana fans can bet the game at BetRivers Indiana)

Big Ten Opening Lines

Staying in the Big Ten, also on tap this week is No. 10 Wisconsin at No. 19 Northwestern. Wisconsin opened as a 7-point road favorite. As a road favorite Wisconsin is 4-2 straight up and ATS in their last six. (Wisconsin Northwestern Matchup Report)

The last ranked matchup in Week 12 is No. 14 Oklahoma State at No. 18 Oklahoma. Oklahoma State may be higher ranked, but they opened as an 8.5-point underdog. Oklahoma has won five straight against their state rivals with a 4-1 ATS record, and at home their 7-1 SU and 5-3 ATS in their last eight versus Oklahoma State.

The largest spread when the opening odds were set this week was in the North Alabama at BYU matchup. BYU opened as a whopping 46-point favorite. When facing a spread of 40 points or higher BYU is 5-0 SU and 3-1-1 ATS in their last five games.

There are five other games with a spread of 30 points or higher this week, starting with Clemson at Florida State. Clemson opened as a 32-point road favorite and when listed as a 30-plus point favorite on the road they’re 3-0 SU, but 0-3 ATS.

Also big road favorites this week is Florida when then visit Vanderbilt. They opened as a 30.5-point road favorite. Florida has only been favored by 30 points or more on the road once in the last 20 years, when they topped Kentucky 44-10 as a 30-point road favorite in 2001.

The other 30-plus point spread on the odds list this week include, Buffalo at Bowling Green (-30), Massachusetts at Florida Atlantic (-30), and tiny Abiliene Christian at Virginia (-35.5).

There are also seven other games with spreads of at least 20 points this week. A select few include Charlotte at Marshall (-21.5), Texas at Kansas (+28.5), Kentucky at Alabama (-29.5) and Mississippi at Georgia (-22.5).

Upcoming Games

Dec 4th, 12:00 PM

Kent State -2 -110

NIU +2 -110


Dec 4th, 12:00 PM

Baylor (9) +6.5 -109

Oklahoma State (5) -6.5 -109


Dec 4th, 3:00 PM

Utah State +3 +100

San Diego State (19) -3 +100


Dec 4th, 3:30 PM

Appalachian State -2 -107

Louisiana-Lafayette (20) +2 -107


Dec 4th, 4:00 PM

Georgia (1) -4 -107

Alabama (4) +4 -107


Dec 4th, 4:00 PM

Houston (16) +10.5 -110

Cincinnati (3) -10.5 -110


Dec 4th, 8:00 PM

Pittsburgh (17) -3.5 -110

Wake Forest (18) +3.5 -110


Dec 4th, 8:00 PM

Michigan (2) -8.5 -108

Iowa (15) +8.5 -108


Dec 4th, 11:00 PM

USC -1.5 -110

California +1.5 -110


Dec 11th, 3:00 PM

Army -8 -110

Navy +8 -110